Conophylline
Jun 05, 2011
5 Comments
Fukuyama, Tokuyama, Han-ya. ACIEE, 2011, 50, 4884. DOI: 10.1002/anie.201100981 
Not a full post, but it’s time to get some of these Chemistry World articles on here. This once is the most recent, in the June issue, and follows Tohru Fukuyama’s synthesis on Conophylline – a really neat piece of work, especially when you consider how sensitive some of the functionality here is. How many of you knew of the Polonovski-Potier reaction?
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I think bis-indole alkaloids are the last untapped frontier of total synthesis. There’s a ton of beautiful structures out there that haven’t been made yet. This is a great example. Thanks for sharing Paul.
Awsome synthesis, yet another notch under Fukuyama’s belt! Great work by a very hard working Japanese team.
Nice to ear back from you!
Oooh! Pick me! I know EXACTLY what the Potier-Polonovski is! Oxidative degradation of alkyl chains between indole and basic nitrogens….I happened across it in a recent paper.
Truly enjoyable. So much of organic chemistry is just increasingly fancy nucleophiles reacting with increasingly fancy electrophiles. And thanks too to Fukuyama for putting his group’s mechanism problem sessions (with possible answers) on the web.